Nitric oxide in follicle development and oocyte competence
نویسندگان
چکیده
منابع مشابه
Metabolism throughout follicle and oocyte development in mammals.
Metabolic studies of mammalian embryos started with the development of in vitro culture systems more than 40 years ago. More recently, metabolic studies have begun to shed light on the requirements of growing oocytes/follicles from the earliest stages of folliculogenesis. While growing oocytes preferentially metabolise pyruvate over glucose, the somatic compartment of ovarian follicles is more ...
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CPEB is a sequence-specific RNA-binding protein that regulates polyadenylation-induced translation. In Cpeb knockout mice, meiotic progression is disrupted at pachytene due to inhibited translation of synaptonemal complex protein mRNAs. To assess the function of CPEB after pachytene, we used the zona pellucida 3 (Zp3) promoter to generate transgenic mice expressing siRNA that induce the destruc...
متن کاملDifferential FSH exposure in preantral follicle culture has marked effects on folliculogenesis and oocyte developmental competence.
BACKGROUND We investigated at what stage early cultured preantral mouse follicles become dependent on a minimal effective FSH dose (10 mIU/ml) and analysed the influence of implementing FSH at several time-points during in vitro culture. METHODS Two-layered mouse follicles were cultured for 12 days under seven different FSH exposure regimens and ovulated on day 13 by hCG/EGF. Ovulated cumulus...
متن کاملOvarian physiology: follicle development, oocyte and hormone relationships
The ovarian follicle is the fundamental unit of the ovary. It contains the oocyte that may eventually ovulate, undergo fertilization and form an embryo. It also provides the steroid and protein hormones required for maintenance of the ovarian cycle, the secondary sex characteristics and preparation of the uterus for implantation. Follicle formation and folliculogenesis have been well documented...
متن کاملP-90: The Effect of Nitric Oxide on Mouse Oocyte in Vitro Maturation in Two and Three Dimensional Conditions
Background: In vitro culture of ovarian follicles may preserve fertility in women with premature ovarian failure due to cancer .It seems that creation a condition that could maintain cellular communications and supports growth of follicles to produce mature oocytes appear to be essential. Nitric oxide (NO) has been recently shown to act with a dual action in mouse oocyte meiotic maturation depe...
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ژورنال
عنوان ژورنال: REPRODUCTION
سال: 2015
ISSN: 1470-1626,1741-7899
DOI: 10.1530/rep-14-0524